radical cyclization造句

• Through radical cyclization a five membered ring is formed followed by the propagation of a new tin radical.
• Approaches to this synthesis are diverse, and include central steps such as annululation, olefin metathesis, radical cyclization, and trapping reactions.
• Followed by a similar radical cyclization resulting in a five membered ring, a new tin radical is produced and the original attacking radical leaves with the sulfur substituent.
• This lack of tight radical pairing is also supported by the observation that alkyl radicals generated by Barton conditions can undergo radical cyclization while analogous intermediates generated by lead tetraacetate oxidation do not.
• "' Disadvantages : "'the relative rates of the various stages of radical cyclization reactions ( and any side reactions ) must be carefully controlled so that cyclization and trapping of the " cyclized " radical is favored.